{"id":1107,"date":"2023-02-22T10:51:24","date_gmt":"2023-02-22T09:51:24","guid":{"rendered":"http:\/\/ea4650.fr\/?p=1107"},"modified":"2023-05-31T16:20:41","modified_gmt":"2023-05-31T14:20:41","slug":"article-fevrier-2023-inhibition-of-epac1-signaling-pathway-alters-atrial-electrophysiology-and-prevents-atrial-fibrillation","status":"publish","type":"post","link":"https:\/\/ea4650.fr\/index.php\/2023\/02\/22\/article-fevrier-2023-inhibition-of-epac1-signaling-pathway-alters-atrial-electrophysiology-and-prevents-atrial-fibrillation\/","title":{"rendered":"Article f\u00e9vrier 2023 : Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.frontiersin.org\/people\/u\/2134277\" target=\"_blank\" rel=\"noreferrer noopener\">Bastien Guillot<\/a>, <a href=\"https:\/\/www.frontiersin.org\/people\/u\/2150194\" target=\"_blank\" rel=\"noreferrer noopener\">Arthur Boileve<\/a>, <a href=\"https:\/\/www.frontiersin.org\/people\/u\/70705\" target=\"_blank\" rel=\"noreferrer noopener\">Richard Walton<\/a>, Alexandre Harfoush, <a href=\"https:\/\/www.frontiersin.org\/people\/u\/2166847\" target=\"_blank\" rel=\"noreferrer noopener\">Caroline Conte<\/a>, <a href=\"https:\/\/www.frontiersin.org\/people\/u\/2158273\" target=\"_blank\" rel=\"noreferrer noopener\">Yannis Sainte-Marie<\/a>, <a href=\"https:\/\/www.frontiersin.org\/people\/u\/2136595\" target=\"_blank\" rel=\"noreferrer noopener\">Sabine Charron<\/a>, <a href=\"https:\/\/www.frontiersin.org\/people\/u\/27381\" target=\"_blank\" rel=\"noreferrer noopener\">Olivier Bernus<\/a>, Alice Recalde, <a href=\"https:\/\/www.frontiersin.org\/people\/u\/709875\" target=\"_blank\" rel=\"noreferrer noopener\">Laurent Sall\u00e9<\/a>, <a href=\"https:\/\/www.frontiersin.org\/people\/u\/1276834\" target=\"_blank\" rel=\"noreferrer noopener\">Fabien Brette<\/a> and <a href=\"https:\/\/www.frontiersin.org\/people\/u\/1805841\" target=\"_blank\" rel=\"noreferrer noopener\">Frank Lezoualc\u2019h<\/a><\/p>\n\n\n\n<p><strong>Introduction:<\/strong> Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased mortality and morbidity. The Exchange Protein directly Activated by cAMP (EPAC), has been implicated in pro-arrhythmic signaling pathways in the atria, but the underlying mechanisms remain unknown.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1120336\/full\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1120336\/full<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bastien Guillot, Arthur Boileve, Richard Walton, Alexandre Harfoush, Caroline Conte, Yannis Sainte-Marie, Sabine Charron, Olivier Bernus, Alice Recalde, Laurent Sall\u00e9, Fabien Brette and Frank Lezoualc\u2019h Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased mortality and morbidity. The Exchange Protein directly Activated by cAMP (EPAC), has been implicated &hellip; <a href=\"https:\/\/ea4650.fr\/index.php\/2023\/02\/22\/article-fevrier-2023-inhibition-of-epac1-signaling-pathway-alters-atrial-electrophysiology-and-prevents-atrial-fibrillation\/\" class=\"more-link\">Continuer la lecture<span class=\"screen-reader-text\"> de &laquo;&nbsp;Article f\u00e9vrier 2023 : Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation&nbsp;&raquo;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1107","post","type-post","status-publish","format-standard","hentry","category-non-classe"],"_links":{"self":[{"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/posts\/1107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/comments?post=1107"}],"version-history":[{"count":6,"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/posts\/1107\/revisions"}],"predecessor-version":[{"id":1143,"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/posts\/1107\/revisions\/1143"}],"wp:attachment":[{"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/media?parent=1107"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/categories?post=1107"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ea4650.fr\/index.php\/wp-json\/wp\/v2\/tags?post=1107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}