Accueil d’un nouveau doctorant

Bienvenue à Corentin KEREVEL dont le sujet de thèse est : Influence des canaux cationiques sur le remodelage de la valve aortique ; financement d’allocation doctorale du Ministère de l’Enseignement Supérieur, de la Recherche et de l’Innovation (MESRI)

ESC Working Group on Cardiac Cellular Electrophysiology

(12-14 june 2023 Copenhagen)

The ESC Working Group on Cardiac Cellular Electrophysiology provides a friendly and informal environment favouring free exchange of ideas in the fields of cardiac ion channel physiology, excitation-contraction coupling, myocardial electrophysiology and related fields of cardiac physiology and pathophysiology.

Thank you to the organizers of this congress and congratulations to our doctoral students ; Arthur BOILEVE for his oral presentation entitled: Exchange Proteins directly Activated by cAMP (EPAC) modulate cardiomyocytes electrophysiology and promote arrhythmogenic ectopic activity in human atria and Margaux AIZE for his poster: Transient Receptor Potential Melastatin 4 (TRPM4) mediates osteogenic differentiation of human valvular interstitial cells.

Journée Normande de Recherche Biomédicale (JNRB)

La 6e Journée Normande de Recherche Biomédicale 2023 a eu lieu le jeudi 8 juin à Caen au PFRS – Pôle des formations et de recherche en santé

Nous remercions les membres organisateurs du congrès et nos doctorants : Arthur BOILEVE pour sa présentation de poster ainsi que Margaux AIZE pour sa présentation orale.

Printemps de la Cardiologie 2023 à Marseille

Recherche Fondamentale et Clinique

Nous remercions les membres organisateurs du congrès de nous avoir accueilli à Marseille pour cette édition 2023 du Printemps de la Cardiologie qui a eu lieu du 24 au 26 mai.

Merci à nos doctorants Arthur BOILEVE et Margaux AIZE pour avoir participés et présentés leurs travaux lors de ce congrès.

Review mars 2023 : Ion Channels in the Development and Remodeling of the Aortic Valve

Christophe SimardMargaux AizeSébastien ChaigneHarlyne Mpweme BangandoRomain Guinamard


The role of ion channels is extensively described in the context of the electrical activity of excitable cells and in excitation-contraction coupling. They are, through this phenomenon, a key element for cardiac activity and its dysfunction. They also participate in cardiac morphological remodeling, in particular in situations of hypertrophy. Alongside this, a new field of exploration concerns the role of ion channels in valve development and remodeling. Cardiac valves are important components in the coordinated functioning of the heart by ensuring unidirectional circulation essential to the good efficiency of the cardiac pump. In this review, we will focus on the ion channels involved in both the development and/or the pathological remodeling of the aortic valve. Regarding valve development, mutations in genes encoding for several ion channels have been observed in patients suffering from malformation, including the bicuspid aortic valve. Ion channels were also reported to be involved in the morphological remodeling of the valve, characterized by the development of fibrosis and calcification of the leaflets leading to aortic stenosis. The final stage of aortic stenosis requires, until now, the replacement of the valve. Thus, understanding the role of ion channels in the progression of aortic stenosis is an essential step in designing new therapeutic approaches in order to avoid valve replacement.

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Article février 2023 : Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

Bastien Guillot, Arthur Boileve, Richard Walton, Alexandre Harfoush, Caroline Conte, Yannis Sainte-Marie, Sabine Charron, Olivier Bernus, Alice Recalde, Laurent Sallé, Fabien Brette and Frank Lezoualc’h

Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased mortality and morbidity. The Exchange Protein directly Activated by cAMP (EPAC), has been implicated in pro-arrhythmic signaling pathways in the atria, but the underlying mechanisms remain unknown.